With a medical, scientific, and philanthropic career that spans more than 30 years, Dr. Sue Desmond-Hellmann has devoted her life to improving the human condition through innovation. Most recently, she was the CEO of the Bill & Melinda Gates Foundation, leading the organization’s vision for a world where every person has the opportunity to live a healthy, productive life. She was formerly the first female chancellor of University of California at San Francisco and spent 14 years at biotech firm Genentech, leading the development of a number of breakthrough medicines. An innovator and leader in life sciences, Dr. Desmond-Hellmann’s diverse training as an oncologist, scientist, and business executive leads to her endless curiosity about the world and her desire to change it for the better. In speeches, she shares her unique insights not only on revolutionizing global health, but also on effective and innovative leadership. Using lessons-learned as a trailblazing female leader of one of the world’s largest philanthropies, Dr. Desmond-Hellmann inspires audiences with her unparalleled perspective on how to foster an environment of collaboration and relentless innovation to drive disruptive solutions that make an impact.

Poppy Jamie is an entrepreneur, influencer, and rising star in the happiness, mental health, and mindfulness space. She is the founder of the mental wellbeing company and app Happy Not Perfect – a source to better brain health. A deeply personal project combining behavioral scientific research, inspiration from her mother, and real life-experience, she created Happy Not Perfect to inspire and empower people to take control of their mental health through products, services, and experiences. As organizations worldwide grapple with how to manage the growing mental health crisis, Poppy provides a clear path to overcoming uncertainty, fears of rejection, anxiety, and burnout to find peace with the past and create a happier, healthier future. She is also author of the anticipated book Happy Not Perfect.

Crystal Washington, CSP works with organizations that want to leverage technology to increase profits and productivity! As a technology strategist and certified futurist, Crystal takes complex social media, app, and web topics, and makes them easy to understand and accessible for everyday people. Crystal’s clients comprise Fortune 500 companies including Google, Microsoft, and GE and as a sought-after keynote speaker, she has entertained and educated audiences around the globe. She has appeared in numerous publications including Entrepreneur, Bloomberg Businessweek, and Forbes and is regularly called on by major television networks as a tech expert. Crystal is the author of the books One Tech Action and The Social Media Why.

Amy Harder is executive editor of Cipher by Breakthrough Energy. Amy is one of the top national energy and climate change reporters in the country, having built up a reputation of being a uniquely balanced and influential journalist with respect across the spectrum. She joined Breakthrough Energy in early 2021 to help launch Cipher, a publication covering the opportunities and challenges of the energy transition.

Marga Hoek is a member of Thinkers50, she is that rare combination: a true visionary on sustainable business and capital and a successful, innovative business leader who understands and applies the commercial realities of business. Operating at the highest level with ministers and presidents, Marga is a global voice for G20, G7 Climate Change and Cop 23 and a regular contributor for prestigious, global media like Forbes Magazine, Fortune and The Huffington Post. Her latest book The Trillion Dollar Shift, on the business opportunities of the Sustainable Development Goals, received an international, gold medal.

When entrepreneur and former top brand executive Michelle Cordeiro Grant set out to start her own company, she did so with the mission to create a brand, experience, and community that empowers women. What followed was Lively, the ultra-successful activewear-inspired lingerie brand that she built into an industry leader and disruptor in less than 10 years. Introducing "Leisurée" to the world, Cordeiro Grant identified opportunities to turn the apparel market on its head and redefined approaches for leading an organization to success.

Clara is the Founder and Executive Chair of Hearsay Corporation, which provides software to help companies securely manage and measure their presence across Facebook, Twitter, and other social media. In 2007, Clara created the first business application on Facebook with her Faceconnector application, which integrates Facebook and Salesforce CRM.

Sophia Kianni is an Iranian-American environmentalist studying climate science and public policy at Stanford University. She is the founder and executive director of Climate Cardinals, an international nonprofit with 8,000 volunteers in 40+ countries working to translate climate information into over 100 languages. She represents the U.S as the youngest member on the inaugural United Nations Youth Advisory Group on Climate Change. Sophia’s work has been featured in news outlets including Forbes, CNN, Business Insider, BBC, NPR, ELLE, TIME Magazine, The Guardian, NBC, and even on the front page of The Washington Post. She was previously a fellow with PBS NewsHour and has written for news outlets such as MTV News, Cosmopolitan, Refinery 29, and Teen Vogue. She is a prolific public speaker and has spoken at universities across the country including Columbia University, UC Berkeley, Johns Hopkins, Cambridge University, and Harvard University. She gave her debut TED Talk as the closing speaker at the inaugural TED Countdown Conference. She has been named VICE Media's youngest Human of the Year, a National Geographic Young Explorer, and one of Teen Vogue's 21 under 21.

Sandra Taylor is CEO of Sustainable Business International LLC, a consulting business that assists clients at various stages of environmental sustainability and corporate social responsibility in the food and beverage sectors. Previously Sandra was a senior executive with Starbucks Coffee Company in Seattle, where she led global responsibility and sustainability in coffee and cocoa supply chains. She is the author of The Business of Sustainable Wine, published in July 2017. Sandra received her BA from Colorado Women’s college, JD from Boston University School of Law and MBA program from the Bordeaux School of Management/Kedge Business School in France.

Kathy Varol is an expert at driving profit with purpose. Kathy created the Global Purpose (corporate social responsibility) strategy for adidas, a 22 billion dollar global company. Now Kathy helps her clients use purpose to stand out in a competitive environment, attract the best talent, gain consumer loyalty, and fully harness the innovative brainpower of their employees (innovation that keeps them miles ahead of the competition). She shares her deep knowledge and “how-to” with clients, so they can skip the hard lessons and go straight to strategies that work. Kathy has 20 years of experience across brand marketing, strategy, and impact, working at established brands like adidas, MillerCoors, and Microsoft. Through her experience, Kathy has developed a repeatable 4-step process to become a purpose-led brand: The Brand Purpose Model. When businesses embed purpose into the heart of their strategy, they don’t just disrupt their industry. They also bring humanity into the workplace, shape the future, and impact the world.

Acclaimed for her indomitable tenacity and daredevil skills, Olympic silver medalist MyKayla Skinner burst onto the American gymnastics scene when she won the junior individual all-around title at the 2011 American Classic. At 24, she became the oldest U.S. Olympic gymnast since 2004 when she competed in the 2020 Tokyo Olympics, where she brought the trademark resilience and competitive spirit that have earned her a reputation as a powerhouse performer and model teammate, vaulting her way to a silver medal on the global stage. Her optimism, fire, and flair can be felt throughout the room as she provides an Olympian’s perspective on performing at a championship-level in high-pressure situations, overcoming adversity, and charting your own path to achieving your goals.

For 28 years, comedian Kathleen Madigan has been touring 250 nights on the road and squeezing in hour-long filmed specials and performances on every late night show ever made. From 25 appearances on "The Tonight Show" and multiple appearances on Letterman and Conan to recently riding around with Jerry Seinfeld in his internet series "Comedians in Cars Getting Coffee," Madigan is still having a blast and selling out theaters across the country. She's won the American Comedy Award for "Best Female Comedian" and the Phyllis Diller award for "Best Female Comedian." She has written and produced for Lewis Black's "Root of All Evil" on Comedy Central and done multiple USO tours in Iraq and Afghanistan.