With a medical, scientific, and philanthropic career that spans more than 30 years, Dr. Sue Desmond-Hellmann has devoted her life to improving the human condition through innovation. Most recently, she was the CEO of the Bill & Melinda Gates Foundation, leading the organization’s vision for a world where every person has the opportunity to live a healthy, productive life. She was formerly the first female chancellor of University of California at San Francisco and spent 14 years at biotech firm Genentech, leading the development of a number of breakthrough medicines. An innovator and leader in life sciences, Dr. Desmond-Hellmann’s diverse training as an oncologist, scientist, and business executive leads to her endless curiosity about the world and her desire to change it for the better. In speeches, she shares her unique insights not only on revolutionizing global health, but also on effective and innovative leadership. Using lessons-learned as a trailblazing female leader of one of the world’s largest philanthropies, Dr. Desmond-Hellmann inspires audiences with her unparalleled perspective on how to foster an environment of collaboration and relentless innovation to drive disruptive solutions that make an impact.

Amy Harder is executive editor of Cipher by Breakthrough Energy. Amy is one of the top national energy and climate change reporters in the country, having built up a reputation of being a uniquely balanced and influential journalist with respect across the spectrum. She joined Breakthrough Energy in early 2021 to help launch Cipher, a publication covering the opportunities and challenges of the energy transition.

Marga Hoek is a member of Thinkers50, she is that rare combination: a true visionary on sustainable business and capital and a successful, innovative business leader who understands and applies the commercial realities of business. Operating at the highest level with ministers and presidents, Marga is a global voice for G20, G7 Climate Change and Cop 23 and a regular contributor for prestigious, global media like Forbes Magazine, Fortune and The Huffington Post. Her latest book The Trillion Dollar Shift, on the business opportunities of the Sustainable Development Goals, received an international, gold medal.

Sophia Kianni is an Iranian-American environmentalist studying climate science and public policy at Stanford University. She is the founder and executive director of Climate Cardinals, an international nonprofit with 8,000 volunteers in 40+ countries working to translate climate information into over 100 languages. She represents the U.S as the youngest member on the inaugural United Nations Youth Advisory Group on Climate Change. Sophia’s work has been featured in news outlets including Forbes, CNN, Business Insider, BBC, NPR, ELLE, TIME Magazine, The Guardian, NBC, and even on the front page of The Washington Post. She was previously a fellow with PBS NewsHour and has written for news outlets such as MTV News, Cosmopolitan, Refinery 29, and Teen Vogue. She is a prolific public speaker and has spoken at universities across the country including Columbia University, UC Berkeley, Johns Hopkins, Cambridge University, and Harvard University. She gave her debut TED Talk as the closing speaker at the inaugural TED Countdown Conference. She has been named VICE Media's youngest Human of the Year, a National Geographic Young Explorer, and one of Teen Vogue's 21 under 21.

Sandra Taylor is CEO of Sustainable Business International LLC, a consulting business that assists clients at various stages of environmental sustainability and corporate social responsibility in the food and beverage sectors. Previously Sandra was a senior executive with Starbucks Coffee Company in Seattle, where she led global responsibility and sustainability in coffee and cocoa supply chains. She is the author of The Business of Sustainable Wine, published in July 2017. Sandra received her BA from Colorado Women’s college, JD from Boston University School of Law and MBA program from the Bordeaux School of Management/Kedge Business School in France.

Kathy Varol is an expert at driving profit with purpose. Kathy created the Global Purpose (corporate social responsibility) strategy for adidas, a 22 billion dollar global company. Now Kathy helps her clients use purpose to stand out in a competitive environment, attract the best talent, gain consumer loyalty, and fully harness the innovative brainpower of their employees (innovation that keeps them miles ahead of the competition). She shares her deep knowledge and “how-to” with clients, so they can skip the hard lessons and go straight to strategies that work. Kathy has 20 years of experience across brand marketing, strategy, and impact, working at established brands like adidas, MillerCoors, and Microsoft. Through her experience, Kathy has developed a repeatable 4-step process to become a purpose-led brand: The Brand Purpose Model. When businesses embed purpose into the heart of their strategy, they don’t just disrupt their industry. They also bring humanity into the workplace, shape the future, and impact the world.

For 28 years, comedian Kathleen Madigan has been touring 250 nights on the road and squeezing in hour-long filmed specials and performances on every late night show ever made. From 25 appearances on "The Tonight Show" and multiple appearances on Letterman and Conan to recently riding around with Jerry Seinfeld in his internet series "Comedians in Cars Getting Coffee," Madigan is still having a blast and selling out theaters across the country. She's won the American Comedy Award for "Best Female Comedian" and the Phyllis Diller award for "Best Female Comedian." She has written and produced for Lewis Black's "Root of All Evil" on Comedy Central and done multiple USO tours in Iraq and Afghanistan.

Originally from Kent in England, Liv Boeree is one of the most successful female poker players of all time, with over $3 million in live tournament earnings. She previously studied at the University of Manchester, achieving a first-class degree in Astrophysics, as well as being in demand as a model and TV presenter on a range of different shows.

Roger Harrabin is one of the media’s most influential voices on the environment, energy and climate change. He is Energy and Environment Analyst for the BBC, where he has broadcast for more than 30 years. Roger has been a global pioneer in environment reporting. He was founder presenter of the BBC environment programme Costing the Earth and has won many awards for his work in radio and TV. His quest for impartiality led him to broadcast two three-part series on Radio 4 tackling the risks and uncertainties in climate science and technology. His reporting on new topics has often been trend-setting – he was, for instance, the first mainstream reporter to highlight the central role that energy would play in the environment. He has interviewed many influential figures including Margaret Thatcher, Tony Blair, Ban Ki Moon, Al Gore and Sir David Attenborough.

Alexis Glick is a distinguished c-suite executive, seasoned television personality, and highly accomplished business leader with a versatile career that spans the realms of finance, media, sports, philanthropy, and energy. Most recently, Glick served as CEO of Nature Energy North America, where she helped execute and lead the sale of the largest biomethane producer to oil giant Shell, marking the largest deal ever recorded in the industry. Glick, responsible for North American growth, successfully delivered two multibillion-dollar Joint Development Agreements (JDAs) with some of North America's most respected gas utility companies and helped lead Nature Energy’s expansion globally. Her expertise in sustainability, ESG, and helping companies address their scope 1, 2, and 3 emissions, achieve NetZero goals, and decarbonize their operations spans over a decade. Glick is a recognized business leader, a veteran media personality, and a former Wall Street executive. She is a frequent contributor to numerous national and international news programs, offering her insights into global markets, the interplay of finance and politics, and ESG matters. Her proven track record of building, developing, and leading high-growth teams, navigating turnarounds, and delivering results in rapidly changing environments has made her a sought-after expert for corporate, private equity, and venture-backed firms.

From the Baltimore Opera to QVC shopping channel, Executive Producer and TV Host Mike Rowe has had hundreds of jobs and relished his role as a chronic freelancer. He’s best known as the “dirtiest man on TV,” a title he earned on the hit TV series Dirty Jobs, where he traversed all 50 states; completed 300 different jobs; and transformed cable television into a landscape of swamps, sewers, and coal mines. He has narrated hundreds of documentaries about space, nature, dinosaurs, and how stuff works. Mike also runs the mikeroweWORKS Foundation, a 501(c)(3) public charity that works hard to debunk myths about the skilled trades and help close the skills gap.

Shayla Rivera is an aerospace engineer and former NASA rocket scientist turned salesperson, corporate trainer, and now international keynote speaker, TEDx speaker, radio host, emcee/host, comedian, actor, writer, producer, seminar facilitator, panel moderator and, as of 2017, director of the ENGR[x] program and Professor of Practice with the College of Engineering at Texas A&M University. However, none of these labels tells you much about her. She best describes herself as a spiritually irreverent mystic and awareness expert. What many would call a Renaissance Woman.