With a medical, scientific, and philanthropic career that spans more than 30 years, Dr. Sue Desmond-Hellmann has devoted her life to improving the human condition through innovation. Most recently, she was the CEO of the Bill & Melinda Gates Foundation, leading the organization’s vision for a world where every person has the opportunity to live a healthy, productive life. She was formerly the first female chancellor of University of California at San Francisco and spent 14 years at biotech firm Genentech, leading the development of a number of breakthrough medicines. An innovator and leader in life sciences, Dr. Desmond-Hellmann’s diverse training as an oncologist, scientist, and business executive leads to her endless curiosity about the world and her desire to change it for the better. In speeches, she shares her unique insights not only on revolutionizing global health, but also on effective and innovative leadership. Using lessons-learned as a trailblazing female leader of one of the world’s largest philanthropies, Dr. Desmond-Hellmann inspires audiences with her unparalleled perspective on how to foster an environment of collaboration and relentless innovation to drive disruptive solutions that make an impact.

Amy Harder is executive editor of Cipher by Breakthrough Energy. Amy is one of the top national energy and climate change reporters in the country, having built up a reputation of being a uniquely balanced and influential journalist with respect across the spectrum. She joined Breakthrough Energy in early 2021 to help launch Cipher, a publication covering the opportunities and challenges of the energy transition.

Sam Rad combines the mindsets of an anthropologist and technologist, bringing her “radical next” perspectives on what’s in store for the future. With the charisma of a rockstar, curiosity of an anthropologist, creativity of an entrepreneur, and calm confidence of an ex-professional skydiver, Sam effortlessly guides organizations and individuals to thrive in times of radical and accelerating change. Through her signature candid and clever delivery, Sam distills complex topics while leading the audience on a compelling, informative, and approachable journey of educational storytelling.

Marga Hoek is a member of Thinkers50, she is that rare combination: a true visionary on sustainable business and capital and a successful, innovative business leader who understands and applies the commercial realities of business. Operating at the highest level with ministers and presidents, Marga is a global voice for G20, G7 Climate Change and Cop 23 and a regular contributor for prestigious, global media like Forbes Magazine, Fortune and The Huffington Post. Her latest book The Trillion Dollar Shift, on the business opportunities of the Sustainable Development Goals, received an international, gold medal.

With more questions than answers in today’s economic landscape, Dana Peterson, chief economist for the Conference Board, has established herself as a visionary, and the go to expert providing insightful analysis and predictions to corporations, associations, and government organizations looking for clarity and foresight into how economic drivers might impact their businesses in the short- and long-term. With over a decade of experience in the field, she serves as the globally recognized think tank’s public face and primary spokesperson on all things related to the economy.

Sophia Kianni is an Iranian-American environmentalist studying climate science and public policy at Stanford University. She is the founder and executive director of Climate Cardinals, an international nonprofit with 8,000 volunteers in 40+ countries working to translate climate information into over 100 languages. She represents the U.S as the youngest member on the inaugural United Nations Youth Advisory Group on Climate Change. Sophia’s work has been featured in news outlets including Forbes, CNN, Business Insider, BBC, NPR, ELLE, TIME Magazine, The Guardian, NBC, and even on the front page of The Washington Post. She was previously a fellow with PBS NewsHour and has written for news outlets such as MTV News, Cosmopolitan, Refinery 29, and Teen Vogue. She is a prolific public speaker and has spoken at universities across the country including Columbia University, UC Berkeley, Johns Hopkins, Cambridge University, and Harvard University. She gave her debut TED Talk as the closing speaker at the inaugural TED Countdown Conference. She has been named VICE Media's youngest Human of the Year, a National Geographic Young Explorer, and one of Teen Vogue's 21 under 21.

Sandra Taylor is CEO of Sustainable Business International LLC, a consulting business that assists clients at various stages of environmental sustainability and corporate social responsibility in the food and beverage sectors. Previously Sandra was a senior executive with Starbucks Coffee Company in Seattle, where she led global responsibility and sustainability in coffee and cocoa supply chains. She is the author of The Business of Sustainable Wine, published in July 2017. Sandra received her BA from Colorado Women’s college, JD from Boston University School of Law and MBA program from the Bordeaux School of Management/Kedge Business School in France.

Kathy Varol is an expert at driving profit with purpose. Kathy created the Global Purpose (corporate social responsibility) strategy for adidas, a 22 billion dollar global company. Now Kathy helps her clients use purpose to stand out in a competitive environment, attract the best talent, gain consumer loyalty, and fully harness the innovative brainpower of their employees (innovation that keeps them miles ahead of the competition). She shares her deep knowledge and “how-to” with clients, so they can skip the hard lessons and go straight to strategies that work. Kathy has 20 years of experience across brand marketing, strategy, and impact, working at established brands like adidas, MillerCoors, and Microsoft. Through her experience, Kathy has developed a repeatable 4-step process to become a purpose-led brand: The Brand Purpose Model. When businesses embed purpose into the heart of their strategy, they don’t just disrupt their industry. They also bring humanity into the workplace, shape the future, and impact the world.

A forward-thinking expert on the digital future and the possibilities new technology presents to reshape society and the ways businesses operate, Melanie Subin is a leading futurist who provides strategic foresight, insights development, corporate innovation and transformation strategies, and strategic management and design processes that help to position organizations in every industry for sustainable success. Subin currently serves as the managing director for the Future Today Institute, a foresight and strategy firm founded by world-renowned futurist Amy Webb that leverages research, signals, and trends to help businesses reduce uncertainty and prepare for plausible futures. Throughout her career, she has assessed the impact of major external forces, such as climate change, increased technological sophistication, changing consumer and business preferences, and rising connectivity on the risks and opportunities facing small, medium, and large businesses across the globe.

For 28 years, comedian Kathleen Madigan has been touring 250 nights on the road and squeezing in hour-long filmed specials and performances on every late night show ever made. From 25 appearances on "The Tonight Show" and multiple appearances on Letterman and Conan to recently riding around with Jerry Seinfeld in his internet series "Comedians in Cars Getting Coffee," Madigan is still having a blast and selling out theaters across the country. She's won the American Comedy Award for "Best Female Comedian" and the Phyllis Diller award for "Best Female Comedian." She has written and produced for Lewis Black's "Root of All Evil" on Comedy Central and done multiple USO tours in Iraq and Afghanistan.

Originally from Kent in England, Liv Boeree is one of the most successful female poker players of all time, with over $3 million in live tournament earnings. She previously studied at the University of Manchester, achieving a first-class degree in Astrophysics, as well as being in demand as a model and TV presenter on a range of different shows.

Linda Bernardi lives and breathes technology disruption and innovation. She is currently Co-Founder and CEO of XdMind Inc., a revolutionary company using AI to dynamically adapt music to video gaming. Today, technology is evolving like never before, and Linda is involved in creating cutting-edge technologies across all sectors, including finance, retail, healthcare, high-tech, logistics, automotive, consumer goods, and all others. Her focus is to enable all enterprises to imagine, disrupt, innovate at record pace, and make the impossible become possible. She works with startups all around the globe, as well as large companies, to enable and inspire enterprises to build a culture of mindful innovation. She loves to practice the beautiful Art of Imagination – the first step towards innovation. Linda believes that the best ideas are the ‘crazy’ ideas, stemming from a keen sense of unbounded imagination, and she works to unleash people’s imaginations.