With a medical, scientific, and philanthropic career that spans more than 30 years, Dr. Sue Desmond-Hellmann has devoted her life to improving the human condition through innovation. Most recently, she was the CEO of the Bill & Melinda Gates Foundation, leading the organization’s vision for a world where every person has the opportunity to live a healthy, productive life. She was formerly the first female chancellor of University of California at San Francisco and spent 14 years at biotech firm Genentech, leading the development of a number of breakthrough medicines. An innovator and leader in life sciences, Dr. Desmond-Hellmann’s diverse training as an oncologist, scientist, and business executive leads to her endless curiosity about the world and her desire to change it for the better. In speeches, she shares her unique insights not only on revolutionizing global health, but also on effective and innovative leadership. Using lessons-learned as a trailblazing female leader of one of the world’s largest philanthropies, Dr. Desmond-Hellmann inspires audiences with her unparalleled perspective on how to foster an environment of collaboration and relentless innovation to drive disruptive solutions that make an impact.

Sophia Kianni is an Iranian-American environmentalist studying climate science and public policy at Stanford University. She is the founder and executive director of Climate Cardinals, an international nonprofit with 8,000 volunteers in 40+ countries working to translate climate information into over 100 languages. She represents the U.S as the youngest member on the inaugural United Nations Youth Advisory Group on Climate Change. Sophia’s work has been featured in news outlets including Forbes, CNN, Business Insider, BBC, NPR, ELLE, TIME Magazine, The Guardian, NBC, and even on the front page of The Washington Post. She was previously a fellow with PBS NewsHour and has written for news outlets such as MTV News, Cosmopolitan, Refinery 29, and Teen Vogue. She is a prolific public speaker and has spoken at universities across the country including Columbia University, UC Berkeley, Johns Hopkins, Cambridge University, and Harvard University. She gave her debut TED Talk as the closing speaker at the inaugural TED Countdown Conference. She has been named VICE Media's youngest Human of the Year, a National Geographic Young Explorer, and one of Teen Vogue's 21 under 21.

Sandra Taylor is CEO of Sustainable Business International LLC, a consulting business that assists clients at various stages of environmental sustainability and corporate social responsibility in the food and beverage sectors. Previously Sandra was a senior executive with Starbucks Coffee Company in Seattle, where she led global responsibility and sustainability in coffee and cocoa supply chains. She is the author of The Business of Sustainable Wine, published in July 2017. Sandra received her BA from Colorado Women’s college, JD from Boston University School of Law and MBA program from the Bordeaux School of Management/Kedge Business School in France.

Amy Harder is executive editor of Cipher by Breakthrough Energy. Amy is one of the top national energy and climate change reporters in the country, having built up a reputation of being a uniquely balanced and influential journalist with respect across the spectrum. She joined Breakthrough Energy in early 2021 to help launch Cipher, a publication covering the opportunities and challenges of the energy transition.

Kathy Varol is an expert at driving profit with purpose. Kathy created the Global Purpose (corporate social responsibility) strategy for adidas, a 22 billion dollar global company. Now Kathy helps her clients use purpose to stand out in a competitive environment, attract the best talent, gain consumer loyalty, and fully harness the innovative brainpower of their employees (innovation that keeps them miles ahead of the competition). She shares her deep knowledge and “how-to” with clients, so they can skip the hard lessons and go straight to strategies that work. Kathy has 20 years of experience across brand marketing, strategy, and impact, working at established brands like adidas, MillerCoors, and Microsoft. Through her experience, Kathy has developed a repeatable 4-step process to become a purpose-led brand: The Brand Purpose Model. When businesses embed purpose into the heart of their strategy, they don’t just disrupt their industry. They also bring humanity into the workplace, shape the future, and impact the world.

Tracy Walder shares her incredible true story of a young woman who went straight from her college sorority to the CIA where, as a covert operative for CIA’s Counterterrorism Center, she assumed aliases, thwarted terrorist attacks, and debriefed terrorists at black sites. After the CIA, she went on to become one of the few women to work both at the CIA and FBI, serving as a Special Agent at the FBI's Los Angeles Field Office and specializing in Chinese counterintelligence operations. Walder details her riveting journey with audiences, offering her unique perspective of a woman in the male-dominated field of special operations. A TED speaker, Walder expertly discusses a range of topics including national security, foreign policy, education, and the role of women in law enforcement and intelligence and shares her impactful message: don't try to change who you are to fit what you think the job wants you to be.

Marga Hoek is a member of Thinkers50, she is that rare combination: a true visionary on sustainable business and capital and a successful, innovative business leader who understands and applies the commercial realities of business. Operating at the highest level with ministers and presidents, Marga is a global voice for G20, G7 Climate Change and Cop 23 and a regular contributor for prestigious, global media like Forbes Magazine, Fortune and The Huffington Post. Her latest book The Trillion Dollar Shift, on the business opportunities of the Sustainable Development Goals, received an international, gold medal.

A presidential-level communicator with more than three decades experience as a national security official, Beth Sanner is among the most influential voices at the highest levels of American intelligence. As the senior-most analyst for the entire Intelligence Community (IC), she was a trusted adviser to the President of the United States on our nation’s most important intelligence matters – first as the Office of the Director of National Intelligence’s director of the President’s Daily Brief and later as the Deputy Director of National Intelligence for Mission Integration. Having served in several leadership, staff, policy, and analytic positions in the IC, Sanner has briefed four Presidents and also advised vice presidents, congressional and cabinet officials, and foreign partners; her acumen is highly sought after by our nation’s decisionmakers and organizations across various industries. Sanner uniquely immerses audiences in her talks —making them feel as though they are our nation’s leaders being briefed on hot-button developments with the potential to reshape our world.

Sue M. Gordon is the former Principal Deputy Director of National Intelligence (PDDNI) – the country’s number two ranking intelligence official. As the fifth PDDNI, she co-led the Office of the Director of National Intelligence and oversaw the entire Intelligence Community, comprised of over a dozen agencies that collect information on threats against the United States. In particular, Gordon’s transformative leadership focused on integrating intelligence across the organization, expanding outreach and partnerships, driving innovation, and advancing diversity and inclusion throughout the Community. With nearly four decades of legendary and dedicated service, Gordon has led at every level of the Intelligence Community with roles spanning numerous organizations and disciplines – drawing on this experience to inspire audiences to challenge the status quo, adapt to changing environments, and apply innovation to their business.

At the height of her 37-year career as a distinguished national intelligence leader, Linda Weissgold was among an elite group of trusted advisors who informed the U.S.’s national security strategy. From March 2020 to April 2023, she served as the Central Intelligence Agency’s (CIA) Deputy Director for Analysis, making her the organization’s top analyst. As the CIA’s Deputy Director of Analysis, Weissgold was called upon by the nation’s highest-ranking officials, policymakers, and military leaders to brief them on global risks, emerging trends, and actionable opportunities, and provide the decision advantage needed to navigate the complexities of national security and protect our democracy. Having served seven presidents, including two years as President George W. Bush’s intelligence briefer, Weissgold offers audiences incomparable analysis of the national and global intelligence landscapes and their impact on organizations and society. Weissgold’s contributions to the Intelligence Community have been recognized with numerous awards and honors, including the Presidential Rank Award — the most prestigious award for outstanding career senior leaders in the federal workforce. She is also the recipient of the CIA’s Distinguished Intelligence Medal, Distinguished Career in Intelligence Medal, and Director’s awards, as well as the William Langer Award.

Few people have had the immense impact that Meghan O’Sullivan has had at the highest levels of geopolitics. She is a globally respected geopolitical expert who has advised the nation’s highest-ranking leaders — from President George W. Bush to Secretary of State Antony Blinken — on some of the most-complex challenges in international affairs. Currently, Dr. O’Sullivan is the Director of the Belfer Center for Science and International Affairs and the Jeane Kirkpatrick Professor of the Practice of International Affairs at Harvard University’s Kennedy School. There, she leads 300 scholars, practitioners, and staff as they advance the boundaries of international relations, security, technology, science, energy, and the environment. The Belfer Center has consistently been ranked as the world’s top academic think tank.

Margaret Brennan is the moderator of CBS News' Face the Nation with Margaret Brennan and the network's senior foreign affairs correspondent based in Washington, DC. Brennan has reported on politics, international affairs, foreign relations, the economy, and global markets since she joined CBS News in 2012 and was named the White House and senior foreign affairs in 2017. Prior to joining CBS News, Brennan spent a decade covering global finance, anchoring a weekday show on Bloomberg Television called "InBusiness with Margaret Brennan."