With a medical, scientific, and philanthropic career that spans more than 30 years, Dr. Sue Desmond-Hellmann has devoted her life to improving the human condition through innovation. Most recently, she was the CEO of the Bill & Melinda Gates Foundation, leading the organization’s vision for a world where every person has the opportunity to live a healthy, productive life. She was formerly the first female chancellor of University of California at San Francisco and spent 14 years at biotech firm Genentech, leading the development of a number of breakthrough medicines. An innovator and leader in life sciences, Dr. Desmond-Hellmann’s diverse training as an oncologist, scientist, and business executive leads to her endless curiosity about the world and her desire to change it for the better. In speeches, she shares her unique insights not only on revolutionizing global health, but also on effective and innovative leadership. Using lessons-learned as a trailblazing female leader of one of the world’s largest philanthropies, Dr. Desmond-Hellmann inspires audiences with her unparalleled perspective on how to foster an environment of collaboration and relentless innovation to drive disruptive solutions that make an impact.

Michael (Mike) Steep is the founder and former executive director of Stanford Engineering School's Center for Disruptive Technology and Digital Cities and the former senior vice president of global business operations at innovation mega-hub, PARC Xerox. He draws on first-hand experience and anecdotes from time spent with the biggest names in Silicon Valley to instruct audiences on how to get ahead of disruptive innovation. Viewing new technology as opportunity, Mike highlights the importance of allowing innovation to trump company culture and legacies—and not the other way around.

A presidential-level communicator with more than three decades experience as a national security official, Beth Sanner is among the most influential voices at the highest levels of American intelligence. As the senior-most analyst for the entire Intelligence Community (IC), she was a trusted adviser to the President of the United States on our nation’s most important intelligence matters – first as the Office of the Director of National Intelligence’s director of the President’s Daily Brief and later as the Deputy Director of National Intelligence for Mission Integration. Having served in several leadership, staff, policy, and analytic positions in the IC, Sanner has briefed four Presidents and also advised vice presidents, congressional and cabinet officials, and foreign partners; her acumen is highly sought after by our nation’s decisionmakers and organizations across various industries. Sanner uniquely immerses audiences in her talks —making them feel as though they are our nation’s leaders being briefed on hot-button developments with the potential to reshape our world.

Sue M. Gordon is the former Principal Deputy Director of National Intelligence (PDDNI) – the country’s number two ranking intelligence official. As the fifth PDDNI, she co-led the Office of the Director of National Intelligence and oversaw the entire Intelligence Community, comprised of over a dozen agencies that collect information on threats against the United States. In particular, Gordon’s transformative leadership focused on integrating intelligence across the organization, expanding outreach and partnerships, driving innovation, and advancing diversity and inclusion throughout the Community. With nearly four decades of legendary and dedicated service, Gordon has led at every level of the Intelligence Community with roles spanning numerous organizations and disciplines – drawing on this experience to inspire audiences to challenge the status quo, adapt to changing environments, and apply innovation to their business.

A mission-driven innovator and entrepreneur, Seth Goldman is the founder of Eat the Change, a planet-friendly snack company and platform to inform and empower consumers to make dietary choices aligned with their concerns around climate and health. The first business launched under the Eat the Change umbrella was PLNT Burger, which is a plant-based quick-serve restaurant that offers delicious burgers, sandwiches, fries, and soft-serve. Goldman also serves as chair of the board of Beyond Meat, a publicly traded California-based enterprise on the cutting edge of plant-based protein.

Amy Harder is executive editor of Cipher by Breakthrough Energy. Amy is one of the top national energy and climate change reporters in the country, having built up a reputation of being a uniquely balanced and influential journalist with respect across the spectrum. She joined Breakthrough Energy in early 2021 to help launch Cipher, a publication covering the opportunities and challenges of the energy transition.

Marga Hoek is a member of Thinkers50, she is that rare combination: a true visionary on sustainable business and capital and a successful, innovative business leader who understands and applies the commercial realities of business. Operating at the highest level with ministers and presidents, Marga is a global voice for G20, G7 Climate Change and Cop 23 and a regular contributor for prestigious, global media like Forbes Magazine, Fortune and The Huffington Post. Her latest book The Trillion Dollar Shift, on the business opportunities of the Sustainable Development Goals, received an international, gold medal.

Sophia Kianni is an Iranian-American environmentalist studying climate science and public policy at Stanford University. She is the founder and executive director of Climate Cardinals, an international nonprofit with 8,000 volunteers in 40+ countries working to translate climate information into over 100 languages. She represents the U.S as the youngest member on the inaugural United Nations Youth Advisory Group on Climate Change. Sophia’s work has been featured in news outlets including Forbes, CNN, Business Insider, BBC, NPR, ELLE, TIME Magazine, The Guardian, NBC, and even on the front page of The Washington Post. She was previously a fellow with PBS NewsHour and has written for news outlets such as MTV News, Cosmopolitan, Refinery 29, and Teen Vogue. She is a prolific public speaker and has spoken at universities across the country including Columbia University, UC Berkeley, Johns Hopkins, Cambridge University, and Harvard University. She gave her debut TED Talk as the closing speaker at the inaugural TED Countdown Conference. She has been named VICE Media's youngest Human of the Year, a National Geographic Young Explorer, and one of Teen Vogue's 21 under 21.

Sandra Taylor is CEO of Sustainable Business International LLC, a consulting business that assists clients at various stages of environmental sustainability and corporate social responsibility in the food and beverage sectors. Previously Sandra was a senior executive with Starbucks Coffee Company in Seattle, where she led global responsibility and sustainability in coffee and cocoa supply chains. She is the author of The Business of Sustainable Wine, published in July 2017. Sandra received her BA from Colorado Women’s college, JD from Boston University School of Law and MBA program from the Bordeaux School of Management/Kedge Business School in France.

Kathy Varol is an expert at driving profit with purpose. Kathy created the Global Purpose (corporate social responsibility) strategy for adidas, a 22 billion dollar global company. Now Kathy helps her clients use purpose to stand out in a competitive environment, attract the best talent, gain consumer loyalty, and fully harness the innovative brainpower of their employees (innovation that keeps them miles ahead of the competition). She shares her deep knowledge and “how-to” with clients, so they can skip the hard lessons and go straight to strategies that work. Kathy has 20 years of experience across brand marketing, strategy, and impact, working at established brands like adidas, MillerCoors, and Microsoft. Through her experience, Kathy has developed a repeatable 4-step process to become a purpose-led brand: The Brand Purpose Model. When businesses embed purpose into the heart of their strategy, they don’t just disrupt their industry. They also bring humanity into the workplace, shape the future, and impact the world.

Few people have had the immense impact that Meghan O’Sullivan has had at the highest levels of geopolitics. She is a globally respected geopolitical expert who has advised the nation’s highest-ranking leaders — from President George W. Bush to Secretary of State Antony Blinken — on some of the most-complex challenges in international affairs. Currently, Dr. O’Sullivan is the Director of the Belfer Center for Science and International Affairs and the Jeane Kirkpatrick Professor of the Practice of International Affairs at Harvard University’s Kennedy School. There, she leads 300 scholars, practitioners, and staff as they advance the boundaries of international relations, security, technology, science, energy, and the environment. The Belfer Center has consistently been ranked as the world’s top academic think tank.

Anja Manuel is a founding partner and principal at Rice, Hadley, Gates & Manuel, LLC, a strategic consulting firm, which she co-founded along with former Secretary of State Condoleezza Rice and others. The firm assists CEOs and senior executives at major US companies in key emerging markets such as China, India, and the Middle East. She teaches at Stanford University’s International Policy Studies Program and is a leading expert on globalization, emerging markets, and America’s shifting role in international leadership. Anja is a former State Department official, an international lawyer, and the author of the book, This Brave New World.