With a medical, scientific, and philanthropic career that spans more than 30 years, Dr. Sue Desmond-Hellmann has devoted her life to improving the human condition through innovation. Most recently, she was the CEO of the Bill & Melinda Gates Foundation, leading the organization’s vision for a world where every person has the opportunity to live a healthy, productive life. She was formerly the first female chancellor of University of California at San Francisco and spent 14 years at biotech firm Genentech, leading the development of a number of breakthrough medicines. An innovator and leader in life sciences, Dr. Desmond-Hellmann’s diverse training as an oncologist, scientist, and business executive leads to her endless curiosity about the world and her desire to change it for the better. In speeches, she shares her unique insights not only on revolutionizing global health, but also on effective and innovative leadership. Using lessons-learned as a trailblazing female leader of one of the world’s largest philanthropies, Dr. Desmond-Hellmann inspires audiences with her unparalleled perspective on how to foster an environment of collaboration and relentless innovation to drive disruptive solutions that make an impact.

Mick Ebeling is an American film, television and commercial executive producer as well as an author, entrepreneur and philanthropist. He was named as on one of the Top 50 Most Creative People of 2014, won the SXSW Innovation Award twice in a row (2014 and 2015), and was awarded the 2014 Muhammed Ali Humanitarian of the Year Award. He is the CEO of Not Impossible, an organization that develops creative technology solutions to address real-world problems.

A highly respected political journalist, Jonathan Martin provides sought-after coverage and regularly drives the news by delivering the inside story from the White House and Capitol Hill to the campaign trail well beyond the beltway. As bureau chief and senior political columnist for POLITICO, Martin is among the most trusted reporters in the country with deep connections to the political leaders, power players, and movers and shakers in Washington, D.C. — and across the country. With vast array of sources in both parties and his keen analytical mind, he reveals what’s really happening at the highest levels of American politics.

In an illustrious career that reads like a chronicle of global impact, The Honorable Raj Panjabi has spearheaded groundbreaking policies and programs that have transcended borders on a quest to protect the health of people around the world. Recognized by TIME as one of its “100 Most Influential People in the World,” Dr. Panjabi is a renowned physician and entrepreneur who led President Joe Biden’s pandemic office at the White House National Security Council. Operating at the center of the Covid-19 pandemic response, he played a pivotal role in steering the ship of American health security back on course and helped orchestrate the largest global vaccination campaign in history. Dr. Panjabi’s transformative impact and ability to drive results serve as an effective blueprint for how leaders in any industry can work within their teams to develop solutions to the most pressing challenges they face in their organizations and industries.

Part journalist, part historian, and all shrewd political observer, Ronald (Ron) Brownstein explains the complexities of American politics with lucid precision. As a CNN Senior Political Analyst, Senior Editor for the Atlantic, and Contributing Editor for National Journal, he produces sharp analysis on politics, policy, the electorate, media, healthcare, energy, the press' impact on Americans, and the range of issues informed by his strong sense of American political and national history. Brownstein provides an insider’s look into politics and the media and has twice been a finalist for the Pulitzer Prize. He is also the author of seven best-selling books, and his articles on politics, public policy, and culture have appeared in myriad of major publications and on many broadcast news outlets.

A unique sense of humor and profound dry wit separates Kevin Nealon from other performers. A likable comedian, he got his start as a department store Santa Claus. Now the longest-running cast member of Saturday Night Live, Nealon's familiar face appears in movies such as Happy Gilmore and The Wedding Singer.

Dana Carvey is an American actor and stand-up comedian best known for his work as a cast member on Saturday Night Live. He is also known for playing the role of Garth Algar in the Wayne's World movies. A sidesplitting addition to any audience, Carvey is one of America's most notable comedians.

An actor, comedian, sports commentator, and Emmy Award-winner, Dennis Miller is known as for his voice behind the desk of Saturday Night Live's "Weekend Update" and as the former host of his own television talk show. A recognizable face in comedy and film, Miller's brilliant stand-up, razor-sharp wit, and his creative rants result in edgy hilarity and lively audiences.

“As Long As You’re Asking – A Conversation with Jason Alexander” is an evening of comedy, music, and conversation with the award-winning star of stage and screen in which the audience determines what they want to know the most. Alexander will present a variety of topics for the audience to pick and choose, culminating in behind the scenes stories of his life, career, and social activism. Or ask about anything you’ve always wanted to know and see if he can answer. Alexander has starred on Broadway, in hit films like Pretty Woman and Shallow Hal and, of course, Seinfeld. He is an actor, director, producer, writer, children’s book author, award-winning magician, semi-pro poker player and social/political activist. It’s all on the table and the conversation is completely in your control, making for a once in a lifetime event.

For 28 years, comedian Kathleen Madigan has been touring 250 nights on the road and squeezing in hour-long filmed specials and performances on every late night show ever made. From 25 appearances on "The Tonight Show" and multiple appearances on Letterman and Conan to recently riding around with Jerry Seinfeld in his internet series "Comedians in Cars Getting Coffee," Madigan is still having a blast and selling out theaters across the country. She's won the American Comedy Award for "Best Female Comedian" and the Phyllis Diller award for "Best Female Comedian." She has written and produced for Lewis Black's "Root of All Evil" on Comedy Central and done multiple USO tours in Iraq and Afghanistan.

Amy Holmes is a familiar face with an unconventional voice in political news. As an on-air political analyst, Amy dissects and debates the issues of the day, appearing regularly on CNN, MSNBC, Fox News and PBS. She is the host of the PBS weekly program "In Principle," and the former host of the daily MSNBC morning show Way Too Early. In addition to working with TheBlaze and MSNBC, she co-hosted the Washington Times and Talk Radio Network's America’s Morning News, a nationally-syndicated morning radio show heard coast-to-coast by over 1.5 million listeners daily.

Peter Diamandis, the chairman and CEO of the X PRIZE Foundation and the author of best-selling Abundance, is a dynamic inspirational speaker who shows his audience how to drive and incentivize breakthrough thinking in order to achieve clear, measurable results. He is considered a key figure in the development of the personal spaceflight industry, as the first private-sector manned spaceflight was a result of an X PRIZE competition. He has also founded many other leading, commercial space-flight organizations and won myriad awards for his incredible work.