With a medical, scientific, and philanthropic career that spans more than 30 years, Dr. Sue Desmond-Hellmann has devoted her life to improving the human condition through innovation. Most recently, she was the CEO of the Bill & Melinda Gates Foundation, leading the organization’s vision for a world where every person has the opportunity to live a healthy, productive life. She was formerly the first female chancellor of University of California at San Francisco and spent 14 years at biotech firm Genentech, leading the development of a number of breakthrough medicines. An innovator and leader in life sciences, Dr. Desmond-Hellmann’s diverse training as an oncologist, scientist, and business executive leads to her endless curiosity about the world and her desire to change it for the better. In speeches, she shares her unique insights not only on revolutionizing global health, but also on effective and innovative leadership. Using lessons-learned as a trailblazing female leader of one of the world’s largest philanthropies, Dr. Desmond-Hellmann inspires audiences with her unparalleled perspective on how to foster an environment of collaboration and relentless innovation to drive disruptive solutions that make an impact.

Molly Fletcher is a trailblazer in every sense of the word. She is a rare talent of business wisdom, relationship brilliance and unwavering optimism. As a CEO, she shares her unconventional and unique techniques that made her one of the first female sports agents in the high stakes, big ego world of professional sports and now a successful entrepreneur. As president of client representation for sports and entertainment agency CSE, Molly spent two decades as one of the world’s only female sports agents.

Crystal Washington, CSP works with organizations that want to leverage technology to increase profits and productivity! As a technology strategist and certified futurist, Crystal takes complex social media, app, and web topics, and makes them easy to understand and accessible for everyday people. Crystal’s clients comprise Fortune 500 companies including Google, Microsoft, and GE and as a sought-after keynote speaker, she has entertained and educated audiences around the globe. She has appeared in numerous publications including Entrepreneur, Bloomberg Businessweek, and Forbes and is regularly called on by major television networks as a tech expert. Crystal is the author of the books One Tech Action and The Social Media Why.

Sophia Kianni is an Iranian-American environmentalist studying climate science and public policy at Stanford University. She is the founder and executive director of Climate Cardinals, an international nonprofit with 8,000 volunteers in 40+ countries working to translate climate information into over 100 languages. She represents the U.S as the youngest member on the inaugural United Nations Youth Advisory Group on Climate Change. Sophia’s work has been featured in news outlets including Forbes, CNN, Business Insider, BBC, NPR, ELLE, TIME Magazine, The Guardian, NBC, and even on the front page of The Washington Post. She was previously a fellow with PBS NewsHour and has written for news outlets such as MTV News, Cosmopolitan, Refinery 29, and Teen Vogue. She is a prolific public speaker and has spoken at universities across the country including Columbia University, UC Berkeley, Johns Hopkins, Cambridge University, and Harvard University. She gave her debut TED Talk as the closing speaker at the inaugural TED Countdown Conference. She has been named VICE Media's youngest Human of the Year, a National Geographic Young Explorer, and one of Teen Vogue's 21 under 21.

Sandra Taylor is CEO of Sustainable Business International LLC, a consulting business that assists clients at various stages of environmental sustainability and corporate social responsibility in the food and beverage sectors. Previously Sandra was a senior executive with Starbucks Coffee Company in Seattle, where she led global responsibility and sustainability in coffee and cocoa supply chains. She is the author of The Business of Sustainable Wine, published in July 2017. Sandra received her BA from Colorado Women’s college, JD from Boston University School of Law and MBA program from the Bordeaux School of Management/Kedge Business School in France.

Amy Harder is executive editor of Cipher by Breakthrough Energy. Amy is one of the top national energy and climate change reporters in the country, having built up a reputation of being a uniquely balanced and influential journalist with respect across the spectrum. She joined Breakthrough Energy in early 2021 to help launch Cipher, a publication covering the opportunities and challenges of the energy transition.

Kathy Varol is an expert at driving profit with purpose. Kathy created the Global Purpose (corporate social responsibility) strategy for adidas, a 22 billion dollar global company. Now Kathy helps her clients use purpose to stand out in a competitive environment, attract the best talent, gain consumer loyalty, and fully harness the innovative brainpower of their employees (innovation that keeps them miles ahead of the competition). She shares her deep knowledge and “how-to” with clients, so they can skip the hard lessons and go straight to strategies that work. Kathy has 20 years of experience across brand marketing, strategy, and impact, working at established brands like adidas, MillerCoors, and Microsoft. Through her experience, Kathy has developed a repeatable 4-step process to become a purpose-led brand: The Brand Purpose Model. When businesses embed purpose into the heart of their strategy, they don’t just disrupt their industry. They also bring humanity into the workplace, shape the future, and impact the world.

Corina Burton is a breakthrough entrepreneur who has made a career of disrupting industries where people who look like her are often overlooked. She is a Latina founder, CEO, brand builder, and gamechanger who is driven by her passion for cultivating relationships and increasing profit margins. While balancing her responsibilities as a mother, as well as the other aspects of her personal life, she co-founded CPR Construction Cleaning, which has become one of the fastest-growing companies in its category since she launched it from her kitchen table in 2019. In addition to building a national company with annual revenue surpassing $5.5 million amid the economic uncertainty of the pandemic and the years following, she is the Founder and CEO of Unstoppable Media, and host of the “Unstoppable” podcast, where she shares the captivating stories and experiences of unstoppable people from all walks of life.

Marga Hoek is a member of Thinkers50, she is that rare combination: a true visionary on sustainable business and capital and a successful, innovative business leader who understands and applies the commercial realities of business. Operating at the highest level with ministers and presidents, Marga is a global voice for G20, G7 Climate Change and Cop 23 and a regular contributor for prestigious, global media like Forbes Magazine, Fortune and The Huffington Post. Her latest book The Trillion Dollar Shift, on the business opportunities of the Sustainable Development Goals, received an international, gold medal.

For 28 years, comedian Kathleen Madigan has been touring 250 nights on the road and squeezing in hour-long filmed specials and performances on every late night show ever made. From 25 appearances on "The Tonight Show" and multiple appearances on Letterman and Conan to recently riding around with Jerry Seinfeld in his internet series "Comedians in Cars Getting Coffee," Madigan is still having a blast and selling out theaters across the country. She's won the American Comedy Award for "Best Female Comedian" and the Phyllis Diller award for "Best Female Comedian." She has written and produced for Lewis Black's "Root of All Evil" on Comedy Central and done multiple USO tours in Iraq and Afghanistan.

Combat tests you. Being a beat cop tests you. Life tests you. Three brothers and being the only girl...tests you. Vernice “FlyGirl” Armour has been tested her whole life. A gutsy trailblazer, her resume is an impressive collection of “firsts” including America’s first Black woman combat pilot. She served two tours of duty in Iraq as a Marine. She was also a diversity liaison officer to the Pentagon for Headquarters Marine Corps. After her military service, FlyGirl revved up her career in the private sector as an entrepreneur, consultant to business, and author of Zero to Breakthrough, The 7-Step, Battle-Tested Method for Accomplishing Goals that Matter. As a speaker, FlyGirl unleashes hard-hitting advice and amazing anecdotes from her adventures on the battlefield and in business. She helps individuals and organizations Get Gutsy and build a sustainable inner force and conviction, that results in accomplishing significant goals.

A legendary presence behind one of America’s most beloved television shows, Lindsay Shookus is an Emmy award-winning producer who, for 20 years, worked as a veteran producer for “Saturday Night Live.” During her tenure, as producer and head of the talent department, Shookus was responsible for engineering the show’s success from booking celebrity hosts and musical guests and creating comfort and connections between them and the cast, to scouting rising stars to join the show’s ranks. She played a pivotal role in launching the careers of household names, including Kristin Wiig and Kate McKinnon — cementing her reputation for having a sharp eye for talent within the entertainment industry. She points to her own experiences to lead an on-stage masterclass on personal transformation, building connections, and embracing life’s obstacles on the road to overcoming them.