With a medical, scientific, and philanthropic career that spans more than 30 years, Dr. Sue Desmond-Hellmann has devoted her life to improving the human condition through innovation. Most recently, she was the CEO of the Bill & Melinda Gates Foundation, leading the organization’s vision for a world where every person has the opportunity to live a healthy, productive life. She was formerly the first female chancellor of University of California at San Francisco and spent 14 years at biotech firm Genentech, leading the development of a number of breakthrough medicines. An innovator and leader in life sciences, Dr. Desmond-Hellmann’s diverse training as an oncologist, scientist, and business executive leads to her endless curiosity about the world and her desire to change it for the better. In speeches, she shares her unique insights not only on revolutionizing global health, but also on effective and innovative leadership. Using lessons-learned as a trailblazing female leader of one of the world’s largest philanthropies, Dr. Desmond-Hellmann inspires audiences with her unparalleled perspective on how to foster an environment of collaboration and relentless innovation to drive disruptive solutions that make an impact.

A seasoned leader and gifted entrepreneur, Nate Mook knows what it takes to turn words into action and ideas into impact. For five years, Mook was the CEO of World Central Kitchen, working alongside world-renowned activist and humanitarian Chef José Andrés on the frontlines to ensure people in disaster zones have access to fresh meals and building food resilient systems with locally led solutions. Widely recognized for his expertise in technology, filmmaking, and building nonprofit organizations, Mook brings a Swiss Army knife approach to crafting powerful stories that bring people together and drive change in the world.

Mick Ebeling is an American film, television and commercial executive producer as well as an author, entrepreneur and philanthropist. He was named as on one of the Top 50 Most Creative People of 2014, won the SXSW Innovation Award twice in a row (2014 and 2015), and was awarded the 2014 Muhammed Ali Humanitarian of the Year Award. He is the CEO of Not Impossible, an organization that develops creative technology solutions to address real-world problems.

A mission-driven innovator and entrepreneur, Seth Goldman is the founder of Eat the Change, a planet-friendly snack company and platform to inform and empower consumers to make dietary choices aligned with their concerns around climate and health. The first business launched under the Eat the Change umbrella was PLNT Burger, which is a plant-based quick-serve restaurant that offers delicious burgers, sandwiches, fries, and soft-serve. Goldman also serves as chair of the board of Beyond Meat, a publicly traded California-based enterprise on the cutting edge of plant-based protein.

Widely respected for her unparalleled insights and analysis from the forefront of American politics, Anna Palmer is a trusted voice on the latest — and most accurate — news on congressional leadership, the lobbying industry, presidential campaigns, and the politics of governing for more than 15 years. She is the co-founder and CEO of Punchbowl News, a news community focused on power, people, and politics in Washington. From 2016 to 2020, Palmer was the co-author, along with Jake Sherman, of the top-rated POLITICO Playbook franchise, where they chronicled President Donald Trump’s first term and his relationship with top Congressional leaders. Under their leadership, the platform more than doubled in revenue and tripled its readership. Anna covers the world of Congress and politics, and has successfully chronicled the business of Washington insiders for years. Her stories take readers behind the scenes of the latest breaking news in Washington from lobbyists to the White House and everything in between.

A unique sense of humor and profound dry wit separates Kevin Nealon from other performers. A likable comedian, he got his start as a department store Santa Claus. Now the longest-running cast member of Saturday Night Live, Nealon's familiar face appears in movies such as Happy Gilmore and The Wedding Singer.

Dana Carvey is an American actor and stand-up comedian best known for his work as a cast member on Saturday Night Live. He is also known for playing the role of Garth Algar in the Wayne's World movies. A sidesplitting addition to any audience, Carvey is one of America's most notable comedians.

An actor, comedian, sports commentator, and Emmy Award-winner, Dennis Miller is known as for his voice behind the desk of Saturday Night Live's "Weekend Update" and as the former host of his own television talk show. A recognizable face in comedy and film, Miller's brilliant stand-up, razor-sharp wit, and his creative rants result in edgy hilarity and lively audiences.

“As Long As You’re Asking – A Conversation with Jason Alexander” is an evening of comedy, music, and conversation with the award-winning star of stage and screen in which the audience determines what they want to know the most. Alexander will present a variety of topics for the audience to pick and choose, culminating in behind the scenes stories of his life, career, and social activism. Or ask about anything you’ve always wanted to know and see if he can answer. Alexander has starred on Broadway, in hit films like Pretty Woman and Shallow Hal and, of course, Seinfeld. He is an actor, director, producer, writer, children’s book author, award-winning magician, semi-pro poker player and social/political activist. It’s all on the table and the conversation is completely in your control, making for a once in a lifetime event.

For 28 years, comedian Kathleen Madigan has been touring 250 nights on the road and squeezing in hour-long filmed specials and performances on every late night show ever made. From 25 appearances on "The Tonight Show" and multiple appearances on Letterman and Conan to recently riding around with Jerry Seinfeld in his internet series "Comedians in Cars Getting Coffee," Madigan is still having a blast and selling out theaters across the country. She's won the American Comedy Award for "Best Female Comedian" and the Phyllis Diller award for "Best Female Comedian." She has written and produced for Lewis Black's "Root of All Evil" on Comedy Central and done multiple USO tours in Iraq and Afghanistan.

Peter Diamandis, the chairman and CEO of the X PRIZE Foundation and the author of best-selling Abundance, is a dynamic inspirational speaker who shows his audience how to drive and incentivize breakthrough thinking in order to achieve clear, measurable results. He is considered a key figure in the development of the personal spaceflight industry, as the first private-sector manned spaceflight was a result of an X PRIZE competition. He has also founded many other leading, commercial space-flight organizations and won myriad awards for his incredible work.

One of Silicon Valley's first African American female CEOs, Shellye Archambeau is the former CEO of MetricStream, a Silicon Valley-based, Governance, Risk, Compliance (GRC) apps company that helps organizations around the world improve their business performance. Under Archambeau's leadership, MetricStream has grown into a recognized global market leader with nearly 1,500 employees worldwide. The company has received many awards and recognition for growth, product innovation, and customer success, and has been consistently named a leader in GRC by leading independent analyst firms. Named the “#2 Most Influential African American in Technology” by Business Insider, Archambeau is a sought-after speaker and board member who has presented to Fortune 500 corporations, members of Congress, and associations including Institute of Internal Auditors and NASDAQ. In her talks and her hit book, "Unapologetically Ambitious," she shares her story of overcoming the odds to achieve success, along with strategies to take risks, break barriers, and create success on your own terms.